Category: Jobs

PhD opportunity: Engineering spatial segregation within bacterial hosts for bio-therapeutic protein production

Dr Steffi Frank, a new lecturer in the Department of Biochemical Engineering at UCL has PhD opportunity on micro compartments for protein folding and production.

More information can be found on PRiSM and on FindaPhD:
https://www.prism.ucl.ac.uk/#!/?project=209
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=80249&LID=981

The overall aim of this project is to develop an alternative method to traditional disulphide bond formation approaches (folding in the eukaryotic endoplasmic reticulum and in the periplasm of prokaryotes) by engineering compartmentalisation within the bacterial cytoplasm of bacteria such as E. coli which will allow for an environment that promotes correct protein folding and disulphide bond formation of recombinant proteins.