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Dual Oxidase-Derived Reactive Oxygen Species Against Bacillus thuringiensis and Its Suppression by Eicosanoid Biosynthesis Inhibitors.

Dual Oxidase-Derived Reactive Oxygen Species Against Bacillus thuringiensis and Its Suppression by Eicosanoid Biosynthesis Inhibitors.

Two entomopathogenic micro organism, Xenorhabdus and Photorhabdus, are identified to have the ability to synthesize and secrete eicosanoid biosynthesis inhibitors (EIBs) that may improve pathogenicity of Bacillus thuringiensis (Bt) towards completely different goal bugs. Such enhancements could be defined by the suppression of immune responses within the hemocoel by EIBs. However, little is thought in regards to the position of …

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Interference RNA for hereditary transthyretin amyloidosis

For the first time, the FDA (the US administration responsible for approving new drugs and equivalent to the European EMA) has approved an interference RNA-based therapy to treat hereditary transthyretin amyloidosis (ATTR).ATTR is a rare disease that produces the accumulation of erroneous proteins in different organs, tissues or nerves, making it difficult to function and …

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Genetically modified immunotherapy and virus to treat glioblastoma

Although therapeutic strategies based on either the use of viruses or immunotherapy have already been tested in patients, the combination of both strategies has never been tested in humans before. Genetically modified viruses and immunotherapy are to be used in patients with glioblastoma, the most aggressive brain tumor.What is glioblastoma? What is this methodology based …

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Hot air stream reduces cytotoxicity of light-cured calcium hydroxide based cements

Hot air stream reduces cytotoxicity of light-cured calcium hydroxide based cements

The light-cured calcium hydroxide based cements have incomplete polymerization and unconverted monomers may cause pulp cell harm. The intention of this research was to guage the affect of a heat and scorching air stream on the cytotoxicity of light-cured calcium hydroxide based cements. The supplies Dycal (standard cement), Biocal, Hidrox-Cal, and Ultra-Blend Plus (light-cured calcium …

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An Epigenetic Bioactive Composite Scaffold with Well-aligned Nanofibers for Functional Tendon Tissue Engineering

An Epigenetic Bioactive Composite Scaffold with Well-aligned Nanofibers for Functional Tendon Tissue Engineering

Poor tendon restore is usually a scientific problem as a result of lack of supreme biomaterials. Electrospun aligned fibers, resembling the ultrastructure of tendon, have been beforehand reported to advertise tenogenesis. However, the underlying mechanism is unclear and the aligned fibers alone are usually not succesful sufficient to commit teno-differentiation of stem cells. Here, primarily …

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